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    TBN是一种治疗缺血性卒中的新型临床候选药物,本研究中TBN通过人生就是博合成

    2025-07-10
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    Stroke is one of the most devastating diseases affecting the health and life of human beings.

    TBN, a novel tetramethylpyrazine derivative armed with a powerful free radical-scavenging nitrone moiety, has been reported to reduce cerebral infarction in rats through multi-functional mechanisms of action. TBN may serve as a promising new clinical candidate for the treatment of ischemic stroke.

    Six Cynomolgus macaque monkeys were used for pharmacokinetic study. TBN were given intravenously at doses of 30 and 90mg/kg, 3 monkeys for each dose.

    TBN (purity 99.3%) used in this study was synthesized by Medicilon.

    90.pngReference:

    Zaijun Zhang, et al. Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy. Sci Rep. 2016 Nov 14:6:37148. doi: 10.1038/srep37148.

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